配方类型: |
DRUGS |
配方说明: |
Tablets (Griseofulvin, 250 mg) |
配方组成: |
"Cab-O-Sil" M-7/1.50 Starch Paste (30% W/V)/1.67 "Veegum" F/8.33 "Emdex"/10.00 "Avicel" PH 101/19.16 Lactose/16.67 Griseofulvin (micronized)/41.67 Stearic Acid/1.00 |
配制方法: |
Prepare a wet granulation of griseofulvin. Mix the griseofulvin, lactose, and starch paste and pass through a 14-mesh sieve. Dry the granules in a 60 C oven for 6 h. Collect granules passing through a 20-mesh sieve. Combine griseofulvin granules, "Veegum" F, "Emdex," and "Avicel" PH 101 and mix for 15 min. Add the stearic acid and "Cab-O-Sil" to the mixture and blend for an additional 10 min. Compress. Mean Tablet Wt. (n=20)---597 mg Mean hardness---7 kg Friability---0.27% Disintegration Time (Purified water)---3 min |
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