中文名称：4-(4-氯苯基)-4-羟基哌啶
  • 4-(4-氯苯)-4-羟基哌啶; 4-对氯苯-4-羟基哌啶; 4-(4-氯苯基)-4-羟哌啶
  • 4-(4-chlorophenyl)-4-hydroxypiperidine
  • 4-(4-Chlorophenyl)-4-piperidinol; 4-(4-Chlorophenyl)piperidin-4-ol; TIMTEC-BB SBB003427; 4-(4-Chlorophehyl)-4-piperidinol; 4-(4-Chlorophenyl)piperidinol-4; 4-(p-Chlorophenyl)-4-piperidinol; 4-Hydroxy-4-(4-chlorophenyl)piperidine; 4-Hydroxy-4-(p-chlorophenyl)piperidine; 4-Piperidinol, 4-(4-chlorophenyl)-; 4-(Chlorophenyl)-4-HYDROXYLPIPERIDINE; 4-(4-chlorophenyl)piperidin-4-ol; 4-(4-chlorophenyl)piperidin-4-ol hydrochloride; 4-(4-chlorophenyl)-4-hydroxypiperidinium; 4-(p-Chlorophenyl)-4-hydroxypiperidine
  • 39512-49-7
  • 254-479-8
  • C11H15ClNO
  • 212.6954
  • InChI=1/C11H14ClNO/c12-10-3-1-9(2-4-10)11(14)5-7-13-8-6-11/h1-4,13-14H,5-8H2/p+1
  • 4-(4-氯苯基)-4-羟基哌啶 39512-49-7
  • 139-141℃
  • 344.5°C at 760 mmHg
  • 162.1°C
  • 340 mg/L (20℃)
  • 2.5E-05mmHg at 25°C
  • 由4-氯-α-甲基苯乙烯（[1712-70-5]）经环合，成盐、加成、水解而得。1.环合、成盐将4-氯-α-甲基苯乙烯加到氯化铵和甲醛混合液中，在60℃左右反应至反应液澄清。再加入甲醇，在45℃反应4h，蒸出甲醇，加入浓盐酸，在40-50℃下反应半小时，95-100℃下反应4h，放置过夜。加液碱至pH为10-11。用甲苯提取，减压回收甲苯，余液用丙酮稀释，加乙酸至pH为7，析出结晶，过滤，丙酮洗涤，干燥，得4-对氯苯1,2,3,6-四氢吡啶乙酸盐。2.加成、水解将上述乙酸盐溶解在冰醋酸中，在30℃以下通溴
  •  Xn:Harmful;
  • R22:;
    R36/37/38:;
  • S26:;
    S37/39:;